CCR5 and chondrosarcoma: A study (Liu et al., 2014) on human chondrosarcoma cells revealed that pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor repressed the VEGF production and angiogenesis induced by CCL5/CCR5, suggesting that the PI3K-dependent pathway plays a crucial role in CCL5/CCR5-mediated angiogenesis.