This may be explained by the blockade of one chemokine leading to the upregulated expressions of other cytokines that exacerbate RAS-dependent hypertension, as CCL2 blockade abrogates the enhanced renal macrophage infiltration and interstitial fibrosis in CCL5-deficient mice (Mikolajczyk et al., 2016; Rudemiller et al., 2016). This evidence concerns the gene CCL5 and hypertensive disorder.