TRPV1 and neuroblastoma: Therefore, the main objectives of this study were to (1) determine the involvement of the noradrenergic, TRPV and NMDA receptors in the anti-allodynic and antihyperalgesic effects of zerumbone and (2) observe the change in α2A-adrenoceptor, TRPV1 and NMDA NR2B receptors expression in the brain regions following zerumbone treatment in neuropathic pain conditions as well as complementing our findings with the in vitro LPS-induced SH-SY5Y neuroblastoma neuroinflammation model for peripheral involvement.