Although we did not perform the experiment to observe the effects of nmFGF1 on neuroprotection after stroke, combined with the previous study that FGF1 enhanced neurogenesis after stroke (Cheng et al., 2011), we can speculate one potential mechanism of nmFGF1 neuroprotection was that enhanced angiogenesis might be partially due to improvements in the microenvironment of vessel growth. Here, FGF1 is linked to stroke disorder.