Anti-IL-1β treatment can alleviate brain edema and reduce infarct size after cerebral ischemia (Dziedzic, 2015), and activated protein-1 (AP-1) transcription factor JunD blunts ischemia/reperfusion-induced brain injury via suppression of IL-1β (Diaz-Cañestro et al., 2019). Here, JUND is linked to brain ischemia.