Studies have confirmed that IFN-γ is involved in the infiltration of microglia and inflammatory cells in cerebral ischemia (Li K. et al., 2017), and that IFN-γ also stimulates the production of interferon regulatory factor-1, induces the expression of NOS mRNA, and produces neurotoxic effects (Yilmaz et al., 2006). Here, NOS2 is linked to brain ischemia.