After cerebral ischemia-reperfusion, various cytokines such as IL-1, IFN-γ, TNF-α, and endotoxins can upregulate the expression of ICAM-1 and promote the strong adhesion to, and activation of, lymphocytes, neutrophils, eosinophils, and monocytes to endothelial cells (Li W. et al., 2017). This evidence concerns the gene ICAM1 and Cerebral ischemia.