PPIG and cholestasis: The panel included various nuclear receptor target genes (e.g. from the cytochrome P450 (CYP) superfamily), key players of fatty acid and bile acid metabolism-related pathways as compiled in the AOPs for steatosis and cholestasis (e.g. (Mellor et al., 2016[49]; Vinken, 2015[74]; Vinken et al., 2013[76]), as well as genes recently identified as biomarkers for drug-induced liver injury (e.g. Albrecht et al., 2019[2]; Grinberg et al., 2018[22]).