In this background, we design the present study to measure six selected immuno-modulators and potential activators of MPNSTs—tumorigenesis in sera of a total of 125 NF1 patients, among them 25 had MPNSTs: PD-L1, IGFBP-1, AXL, IFN-α, GM-CSF, and PGE2. Here, AXL is linked to neurofibromatosis type 1.