Moreover, in experimental allergic encephalitis, a mouse model of multiple sclerosis (MS), we find augmented IFNγ expression by cells from Trp73−/− mice and show that these animals have decreased disease severity, whereas in a model of adoptive transfer inflammatory bowel disease, Rag2−/− hosts receiving of p73-deficient naive CD4+ T cells as opposed to wild-type (WT) T cells have augmented Th1 responses as well as greater disease. This evidence concerns the gene CD4 and inflammatory bowel disease.