RAG2 and colitis: Furthermore, at week 7 post T cell transfer, while there was no significant difference in body weights, which is not unexpected at this still early time point in disease development (Supplementary Fig. 7b), Rag2−/− mice receiving Trp73 cKO T cells developed symptoms of colitis including diarrhea, as compared to mice receiving T cells from WT littermates, which displayed no symptoms of colitis.