Our previous work with minipigs has shown that a deletion of exon 42 (NF1+/ex42del), a mutation observed in NF1 patients, mimics early in life, a wide range of phenotypes exhibited by the human population including CALMs, cutaneous and/or plexiform neurofibromas, axillary and inguinal freckling, unidentified bright objects, decreased cognitive abilities22, and increased pain and sleep disturbances34. The gene discussed is NF1; the disease is plexiform neurofibroma.