To examine whether the WT IGFBP-3 peptide operates similarly to the IGFBP-3 protein, we chose to work with a normal human lung cell (HFL1) reported earlier72 to be CD44-negative and two human NSCLC cell lines43, A549 (p53 WT-genotype) expressing relatively high levels of IGFBP-3 and p53, and H1299 (p53-null genotype) that have undetectable levels of IGFBP-373. This evidence concerns the gene CD44 and non-small cell lung carcinoma.