While AChE is well-known for its classical key role in the catalytic hydrolysis of cholinergic neurotransmitters, recent studies have shown non-classical functions of the enzyme as a potentially promising tumor growth suppresser and regulator of apoptosis61, suggesting that elevated AChE expression and/or activity in response to apoptotic stimuli could serve as a marker of apoptosis and promising anticancer therapeutic63,64. Here, ACHE is linked to neoplasm.