The effect of the IGFBP-3 protein and the IGFBP peptides (Table 1) on cell viability was examined in a normal human lung cell (HFL1) reported earlier72 to be CD44-negative and two human NSCLC cell lines43, A549 expressing relatively high levels of IGFBP-3 and p53, and H1299 with undetectable levels of IGFBP-3 and a p53-null genotype due to a biallelic deletion of the TP53 gene73. The gene discussed is IGFBP3; the disease is non-small cell lung carcinoma.