As all the significant SNPs were resided in the intron region of COL6A5 gene, which possesses regulatory functions in pre-mRNA processing42, we considered that alternation at these polymorphic sites might modulate the expression efficiency of COL6A5 mRNA, contributing to the abnormal pattern of COL6A5 and thereby influencing the individual susceptibility to lung cancer. This evidence concerns the gene COL6A5 and lung carcinoma.