The genes CDC6, RRM2, ORC1, NCAPG, MAD2L1, MCM6, CCNF, CDCA2, ECT2, and DEPDC1B, are the output candidate genes identified in explored modules, which are differentially expressed between normal and cancer states, and their differential expression levels have noteworthy effects on the lifespan of patients. The gene discussed is RRM2; the disease is cancer.