Its genes have roles in key pathways involved in colon cancer such as Wnt Signaling Pathway, Apoptosis, Tumor suppressor activity of SMARCB1, G1 to S cell cycle control, TGF-beta Signaling Pathway, H19 action Rb-E2F1 signaling, and CDK-Beta-catenin activity, Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds and lncRNA involvement in canonical Wnt signaling and colorectal cancer. Here, RB1 is linked to malignant colon neoplasm.