We report two previously unrecognized candidate predictive biomarkers to the combination of PARPi niraparib and PD-1 inhibitor pembrolizumab therapy in platinum-resistant ovarian cancer: the presence of mutational signature 3 as a surrogate of HRD and a positive immune score (IS) as a surrogate of interferon-primed, CD8-exhausted effector T-cells in the tumor microenvironment. Here, CD8A is linked to neoplasm.