Wardhana et al.37 observed a modest but significant insulin resistance and glucose intolerance in Fam13a KO mice, while we and Tang et al.36 detected no difference in either insulin sensitivity or glucose tolerance between WT and Fam13a KO mice under both chow and HFD, despite a slightly increased adiposity in Fam13a KO mice after HFD. The gene discussed is INS; the disease is Glucose intolerance.