The present study shows that DNA methylation status has a substantial influence on tumor progression by regulating oncogenes such as Sipa1. Demethylation agents, such as 5-Aza-CdR and 5-Aza-cytidine have been used as chemotherapeutic agents in the treatment of malignancies such as myeloid leukemia (Garcia-Manero et al., 2006; Kornblith et al., 2002). Here, SIPA1 is linked to myeloid leukemia.