In some cancerous tissues such as the breast, prostate and colon, a markedly high level of SIPA1 is expressed, compared with that in the surrounding normal tissues, that may be responsible for cancer metastasis (Minato and Hattori, 2009; Zhang et al., 2015; Shimizu et al., 2011; Ji et al., 2012). This evidence concerns the gene SIPA1 and cancer.