The optimal diet to achieve weight loss and improve glycemic control remains unclear, mainly due to the broad range of diets used in previous studies.7–9 For example, the United Kingdom Prospective Diabetes Study recommended a reduced-calorie diet (50%–55% carbohydrate, 30%–35% fat, 10%–15% protein) in the intensive treatment arm, with or without intensified therapy using sulfonylurea drugs, insulin and/or metformin. Here, INS is linked to diabetes mellitus.