Besides, AKT1 has been widely reported to be a frequently activated kinase in cancers,23,32,33 exerting important functions in regulating cellular activities such as cell proliferation and invasion.19, 20, 21 We then confirmed that circ-AKT1 was highly expressed in CC samples in contrast with the paired non-tumor samples (Figures 1A and 1B). This evidence concerns the gene AKT1 and cancer.