SERPINE1 and myeloid sarcoma: Interestingly, we did observe significantly higher levels of PAI-1 in the CSF of MS patients with more clinical disability, reflected by the EDSS score (0.81 ng/mL ± 0.15 IQR, EDSS score > 5.25) compared with MS patients with a lower disability score (0.66 ng/mL ± 0.08 IQR, EDSS score < 5.25) (t = 2.89, p = 0.009) (Fig. 3c) while the age between these two groups was similar (Supplementary 3f).