Because the RhoA–Rho kinase–MLCP pathway is one of the major contractile mechanism in vascular smooth muscle contraction [23, 24, 26], the novel role of C2α and C2β in Rho–Rho kinase–MLCP pathway may provide some insight about understanding the pathophysiology and development of new therapies for cardiovascular diseases including hypertension and vasospasms. The gene discussed is RHOA; the disease is hypertensive disorder.