Interestingly, the partial deletion of Sgpl1 (Sgpl1+/−) in mice accentuated BLM-induced pulmonary fibrosis in mice [23], suggesting a balance between TGF-β-mediated SPHK1 and S1P lyase expression in regulating S1P levels and fibrogenesis. Here, SGPL1 is linked to pulmonary fibrosis.