To evaluate the potential of using both Chibby and β-catenin nuclear expression in HCC specimens for the prognosis of patients with HCC after resection, univariate analysis showed that alpha-fetoprotein (AFP) level > 200 ng/mL, liver cirrhosis, tumor size > 5 cm, multiple tumor number, TNM stage III and IV, poor histology grade, and HCC with β-catenin (high) and Chibby (low) were risk factors for recurrent HCC. This evidence concerns the gene AFP and neoplasm.