CBY1 and cancer: Although prior studies have documented that overexpression of Chibby in colorectal, lung, and laryngeal squamous cell carcinoma correlate with less aggressive cancer phenotypes [15,16,17], which are consistent with our results, it is noteworthy that the present study is the first study indicating the association between the expression of Chibby and the clinical outcomes, which is different from the prior studies which were only observation from tumor cell lines.