As we know, HCC has wide variations in etiology and inter- and intra-phenotypes, which are involved by various signal transduction pathways, such as TERT, Wnt/β-catenin, p53, chromatin remodeling complexes and epigenetic regulators, RAS-RAF-MAPK, and the oxidative stress pathway [5]. This evidence concerns the gene TERT and hepatocellular carcinoma.