Against the background of suggested links between insulin signaling and neurodegenerative diseases [3,4,5,6,7,8,10,11,12], as well as the pathological relevance of the putamen, prefrontal cortex, and substantia nigra in PD [28], we probed for probable association between diabetes-related insulin resistance and PD using bioinformatics approaches. This evidence concerns the gene INS and Insulin resistance.