PLK2 and Parkinson disease: Consistent with the complicity of mitochondrial dysfunction and oxidative stress in PD, we probed and computationally demonstrated that upon formation of the SNCA/PLK2 complex, the activated SNCA actively interacts with and binds to reactive oxygen species modulator 1 (ROMO1) with a docking score of –244.41, and ligand RMSD of 59.80Å (Figure 7B).