Paradoxically, the very high level of oxidative stress in viral and bacterial infections, in cancer cells and in the cells of patients suffering from inflammatory diseases, such as Huntington’s disease, give reason to hope that the DNA glycosylases hOgg1 and hNeil1 are relevant pharmacological targets in precise pathologic situations [13,15,17,53,54,55,56]. This evidence concerns the gene OGG1 and cancer.