The clinical relevance of anti-CYP2D6 auto-reactivity in autoimmune hepatitis is supported by animal models: mice infection with CYP2D6-expressing Ad5 adenovirus leads to the production of anti-CYP2D6 IgG that cause immune-mediated liver injury by recognizing the same epitopes targeted by human auto-antibodies [240]. Here, CYP2D6 is linked to infection.