To test the involvement of eIF2A in translation of SV 26S mRNA, the authors silenced the expression of eIF2A by means of siRNA interference and found that abrogation of eIF2A expression led to a reduction in the synthesis of SV structural proteins in PKR+/+ cells (that allowed for eIF2α phosphorylation upon viral infection), but not in PKR0/0 cells [84]. Here, EIF2A is linked to viral infectious disease.