Interestingly, in a murine model of biliary atresia, both Nlrp3-/- and Il-1R1-/- mice showed reduced biliary damage and inflammation compared to controls; however, Caspase-1-/- mice were not protected, suggesting that inflammasome activation may result in biliary damage via the activation of non-canonical pathways in this setting [85]. This evidence concerns the gene NLRP3 and biliary atresia.