NLRP3 and Hepatic fibrosis: Cai et al. showed that, while Caspase-1-/- mice subjected to bile duct ligation (BDL) had more severe liver fibrosis, the incubation of hepatocytes or macrophages with cholestatic levels of conjugated bile acids did not stimulate the activation of the inflammasome, suggesting an indirect effect of NLRP3 activation in liver damage [87].