Venn diagram analysis showed that AD and VaD shared 21 transcription factors (IRF1, ZFX, REST, CTCF, PPARG, CREB1, YY1, ARNT, STAT1, GATA1, GATA2, GATA3, SREBF1, SREBF2, RELA, FOXA2, MYB, E2F4, JUN, SRF, ESR1) whereas AD and FTD shared one transcription factor, EGR1. This evidence concerns the gene SREBF1 and Alzheimer disease.