IRX3 and Stillbirth: In summary, this study successfully generated an IRX3-/- Bama minipig model using CRISPR/Cas9 gene editing and somatic cell cloning technology and observed that IRX3-/- donor cells lead to a significant decrease in the production of somatic cell-cloned pigs, which was specifically manifested as a significant reduction in the average live litter size, a marked increase in the average number of litter stillbirths, significant reduction in birth weight of surviving IRX3-/- somatic cell-cloned pigs, and poor viability after birth.