Negative feedback loops have also been detected between genes whose expression is often dysregulated in cancer, which are both targets of the microRNAs and their negative regulators, as in the case of ADAM17 and NEDD9 with miR-145 in RCC and glioma cells, respectively [107,108], of Sox2, which downregulates the expression of the cluster [109], and of LimK1, a negative regulator of miR-143 in Non-Small Cells Lung Cancer (NSCLC) [100]. Here, ADAM17 is linked to non-small cell lung carcinoma.