Tumors with a combined profile of HR competency and lack of the key effector of error-prone NHEJ (RAD51+/53BP1−) at diagnosis demonstrated significantly worst PFS and OS (p = 0.009; p = 0.024) on multivariate analysis, suggesting that efficient DSB repair capacity may protect tumor cells from DNA damage induced by platinum as well as by subsequent lines of chemotherapy. This evidence concerns the gene RAD51 and neoplasm.