TP53BP1 and neoplasm: Tumors with a combined profile of HR competency and lack of the key effector of error-prone NHEJ (RAD51+/53BP1−) at diagnosis demonstrated significantly worst PFS and OS (p = 0.009; p = 0.024) on multivariate analysis, suggesting that efficient DSB repair capacity may protect tumor cells from DNA damage induced by platinum as well as by subsequent lines of chemotherapy.