CD8A and myeloid sarcoma: Furthermore, autoinflammatory CNS diseases may drive lymphocyte activation/differentiation (e.g., differentiation of CD8+ cytotoxic T cells in Rasmussen encephalitis [6] and Susac syndrome (SuS) [7]) and/or intrathecal generation of distinct lymphocyte subsets (e.g., generation of antibody-producing plasmacytoid cells in multiple sclerosis [MS] [8,9,10]).