NOS3 and endothelial dysfunction: miR-200c is an oxidative stress-induced miRNA that has been linked to endothelial dysfunction, since it induces apoptosis and senescence in ECs via the downregulation of ZEB1 protein [106] and induces NO decrease and oxidative stress increase downregulating Sirtuin1 (SIRT1), endothelial nitric oxide synthase (eNOS), and Forkhead boxO1 (FOXO1) [107], three proteins that regulate EC homeostasis [108].