Furthermore, studies on human gastric carcinoma cell lines such as SGC-7901, AGS, NCI-N87, HS 746T, MKN-45, KATO III, NCI-SNU-1, SNU-5, and SNU-16 demonstrated that siRNA-mediated knockdown of UbcH10 expression in gastric cancer cells reduced proliferation rate, increased cisplatin-induced apoptosis and decreased serum-induced ERK, Akt/PKB and p38 phosphorylation [41]. The gene discussed is UBE2C; the disease is gastric cancer.