Furthermore, it has been shown that RNA interference (RNAi) targeting UbcH10 induced growth inhibition, apoptosis, and cell cycle arrest in U-251 glioblastoma cell line, proving the important role for UbcH10 in the regulation of proliferation, apoptosis, and cell cycle progression of glioma cells [22]. The gene discussed is UBE2C; the disease is glioblastoma.