ABCB1 and squamous cell carcinoma: Interestingly, in the lung, squamous cell carcinoma-derived SK-MES-1 cells line the suppression of UbcH10 inhibited cell proliferation, increased chemosensitivity to gemcitabine or paclitaxel, and downregulated the expression ABCB1 gene encoding for the integral membrane-associated protein, named Multidrug Resistance Protein 1, which is involved in extra- and intra-cellular membrane transport [26].