In our previous studies, we evaluated serum CXCL-8 concentrations in gastrointestinal malignancies and revealed that serum concentrations of CXCL-8, similarly to those of the classical tumor markers (SCC-Ag and CEA) are significantly higher in esophageal cancer (OC) patients in comparison to healthy controls [15]. This evidence concerns the gene CEACAM5 and neoplasm.