CXCL8 and colorectal carcinoma: Serum concentrations of CXCL-8 were significantly correlated with the presence of distant metastases (p = 0.003) as well as with serum levels of CEA (p = 0.019) and CRP (p < 0.001) in CRC patients (Table 4).The relationship between several risk factors and CRC risk was initially examined using univariate analysis in order to identify the risk factors which qualified for the multivariate model (results are presented as odds ratios (OR) and p-values).