Numerous studies document ANRIL rs1333049 C/G polymorphism and its correlation withCAD risk and progression (Samani etal., 2007, 2008;Welcome Trust Case Control Consortium,2007; Schunkert et al.,2008; Karvanen et al.,2009; Muendlein et al.,2009; Bressler et al.,2010; Dandona et al.,2010; Ellis et al.,2010; McPherson, 2010; Palomaki et al., 2010; Wang et al., 2010; Mendonça et al., 2011; O’Donnell et al., 2011; Angelakopoulou et al., 2012;Plichart et al., 2012)and ischaemic stroke (Karvanen etal., 2009; Smith etal., 2009). This evidence concerns the gene CDKN2B-AS1 and ischemic stroke.