CD274 and neoplasm: There are various viral products expressed in host cells that resulted in expansion of immunosuppressive cells, evasion of immune recognition by host major histocompatibility complex, and downregulation of various pro-inflammatory cytokines.[2–5] Apart from that, EBV viral proteins have also been implicated in upregulation of immune checkpoint molecule such as Programmed Cell Death Ligand 1 (PD-L1).[6] The expression of PD-L1 results in further downplay of immune attack, thereby it facilitates resistance free tumor progression.