Furthermore, the increased infiltration of tumor-associated macrophages (TAM) (dominated by the M2 macrophages), which may be due to the deletion of the Hippo signaling, has been reported to produce the Wnt/β-catenin signaling and trigger the elevated intramural FoxP3+ Treg population, while this in turn accelerates LIHC progression [40–42]. The gene discussed is FOXP3; the disease is neoplasm.