GSK3B and Alzheimer disease: AD - Alzheimer’s dementia; ADL - activities of daily living; GSK-3B - glycogen synthase kinase 3-beta; Wnt3 - wingless related integration site 3; TgCRND8 - transgenic mice with CRND gene mutation at position 8; ST - stretching and toning; HR - hazard ratio; CI - confidence interval; OD - odds ratio