These changes reduce the neuroinflammation caused by neurofibrillary tangles in Alzheimer's disease. Ohia-Nwoko O studied that exercise improved general locomotor and exploratory activity and resulted in significant reductions in full-length and hyperphosphorylated tau in the spinal cord and hippocampus as well as a reduction in sarkosyl-insoluble AT8-tau in the spinal cord [35]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.