In addition, when comparing the hypercholesterolemia group, the vascular MPO activity decreased from 38.83 ± 5.56 U/g to 11.05 ± 1.43 U/g (P < 0.01; Figure 2(c)) after PIO intervention—an observation that was similar to changes seen after DDC intervention. The gene discussed is MPO; the disease is familial hypercholesterolemia.