To answer these questions, we did experiments in mouse fibroblast NIH-3T3 cells stably harboring each of seven HCC-derived EGFR missense mutants (K757E, N808S, R831C, V897A, P937L, T940A, and M947T), as well as the erlotinib-sensitive L858R-mutant, the erlotinib-resistant T790M-mutant, EGFR wild type (WT), and vector without EGFR. Here, EGFR is linked to hepatocellular carcinoma.