The crystal structures of HCC-derived EGFR mutants in this study were generated and drawn by PyMOL Molecular Graphics System (Version 2.3.2) based on information from the crystal structures of wild-type EGFR in complex with ATP analog-peptide conjugate (PDB ID: 2GS6) [25], and with erlotinib (PDB ID: 1M17) [26]. The gene discussed is EGFR; the disease is hepatocellular carcinoma.