AKT1 and cholangiocarcinoma: However, it remains impossible to rule exclude that the observed “stemness” or CC elements in the murine CHC could be the result of de-differentiation or trans-differentiation of HCCs since recent data suggest that a simultaneous activation of NOTCH and AKT signaling in hepatocytes can trigger cholangiocellular transdifferentiation and the growth of CC [29–31].