The genotype analysis of these SNPs of SMAD7 gene revealed that the CG genotype of rs2337106 (44± 55.0), (15±51.7) and TC genotype of rs6507874 (37± 46.2), (17±58.6) were the most prevalent genotypes in both colon and rectum cancer, respectively. Here, SMAD7 is linked to rectal cancer.