NOS2 and polycystic ovary syndrome: Adropin plays a significant role in other metabolic disorders, such as diabetic nephropathy, polycystic ovary syndrome (PCOS), etc. Studies indicated that adropin can significantly reduce the expressions of TNF-α, IL-6, and inducible NOS (iNOS) at the mRNA level in pancreatic tissues of diabetic rats [28, 29].