NR3C2 and Huntington disease: In the research on early-life stress in mice, long-term changes in Nr3c1 are Nr3c2 expression are usually not found in either males or females [11, 67, 68], although there are isolated reports about enhanced hippocampal Nr3c1 expression in adult MS and HD male mice [69] or decreased cortical Nr3c1 expression in adult MS male mice [70].