In this way, we identified a group of drugs in CMAP database that have higher scores of similarity (connectivity score) of gene-expression profiling as compared to the established enhancing activity in BAT and (or) sWAT signature, thereby potentially activating the UCP1 expression and inducing energy expenditure to combating obesity and associated diseases. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.