In the present study, compared with the control group, groups administered with CF, CF-20, CF-30, and CF-40 all significantly decreased their renal expression of AQP1, AQP2, AQP3, and AQP4 relative to a control group with saline treatment, an effect that was paralleled by a reduction of diuresis. The gene discussed is AQP4; the disease is cystic fibrosis.