In our study, adding medium from cultured tumor cells or IL-6 and VEGF could abrogate the effect of At-EE inhibition of p-STAT3 activation and NF-kB phosphorylation, which demonstrated IL-6, VEGF, and p-STAT3/NF-kB created an autocrine feedback loop in ovarian cancer cells. The gene discussed is STAT3; the disease is ovarian cancer.