CDH1 and gastric cancer: Most patients with GC belong to the genomically stable subtype in the TCGA classification or the microsatellite stable/epithelial-mesenchymal transition subtype in the ACRG classification are of young age, and the common genetic aberrations are mutations in CDH1, RhoA, or CLDN18-ARHGAP rearrangements; thus, it is no surprise that most of these tumors are characterized by higher rates of diffuse histological variants [44, 45].