Increasing evidence revealed that multiple circRNAs were involved in the regulation of cellular phenotype of glioma cells through diverse pathways, functioning as oncogenes, like circHIPK3 [11], hsa-circ-0014359 [12] and circCPA4 [13]; or playing as tumor suppressors, such as circ-FBXW7 [26], circ-SHPRH [27], and circ_0001946 [28]. This evidence concerns the gene FBXW7 and central nervous system cancer.