MTDH and acute myeloid leukemia: Previously, we has proven that downregulation of AEG-1 by shRNA could decrease the levels of p-Akt (Ser473) and pAkt (Thr308) (the active forms of phosphorylated Akt1) mediated by AURKA inactivation in AML cells, which led to a significant decrease in AML proliferation and increase in apoptosis [20].