CASP3 and neoplasm: And in our study, we observed in xenograft tumor cells that Ad-sta-SFv could decrease the expression of several apoptosis-related gene, c-Myc, NF-κB (p65), Akt1, p-Akt (ser473) and p-Akt (Thr308) and cleaved caspase 3 on protein levels in vivo by blocking the function of AEG-1, which forcefully demonstrated Ad-sta-SFv could accelerate cell apoptosis and cause tumor growth inhibition.