In our present study, the stathmin promoter-driving AEG-1 ScFv adenoviral system is endowed with dual-specificity, accurately blocking AEG-1 functions and merely targeting tumor cells, so that it is supposed to significantly outperform targeted-AEG-1 siRNA in practicality for translational medicine since such an adenoviral system can precisely aim at an crucial tumor specific antigen with an effective transportation, as well as greatly avoid undesirable side effect, which make AEG-1 ScFv and AEG-1 ScFv fusion complex therapy a promising strategy for the treatment of human malignant tumors. This evidence concerns the gene STMN1 and neoplasm.