Further, many scientists have proposed that AEG-1 might be a novel prognostic marker on the basis of their investigating the correlation between the expression levels of AEG-1 and tumor samples with different clinical stages, whose studies supported that over-expression of AEG-1 was usually associated with lymph nodes/distant metastasis and a poor prognosis [5–7]. This evidence concerns the gene MTDH and neoplasm.