TTR and hepatocellular carcinoma: An increasing amount of research has pinpointed systematic inflammation and abnormal metabolism involved in the diagnosis and progression of HCC, such as fibrinogen (Fib) [15], prealbumin (PA) [16], platelet (PLT) [17], gamma-glutamyl transferase (GGT) [18], and combinations of several single markers in the forms of ratios [19, 20].