AFP and cyclic hematopoiesis: The optimal cut-offs of GPR were 0.23 and 0.20, for the diagnosis of AFP-negative CH (AUC = 0.677, sensitivity = 64.44%, specificity = 61.96%, PPV = 62.4%, and NPV = 64.0%), and AFP-negative LC (AUC = 0.617, sensitivity = 68.89%, specificity = 43.71%, PPV = 59.3%, and NPV = 54.1%), respectively.